Greenfeld’s book persuasively demonstrates the lack of consensus in the scientific community and beyond, over the causes, treatment and prevalence of schizophrenia and manic depression, both in America and worldwide. As this review is being prepared a new edition of the Diagnostic and Statistical Manual of Mental Disorders, or DSM-5, is being released in the United States to some controversy. Liah Greenfeld’s call for a broader understanding of the role of culture in the growth of the illnesses of schizophrenia and manic depression seems perfectly timed to join the debate over the balance between science and culture in the diagnosis and treatment of these complex illnesses.